Ann Infertil Reprod Endocrinol | Volume 2, Issue 1 | Research Article | Open Access
Masashi Yoshida* and Takao Miyake
Miyake Women’s Clinic, Japan
*Correspondance to: Masashi Yoshida
Fulltext PDFBackground: We determined the effect of uterine myomectomy on subsequent pregnancy and delivery in infertility women with uterine leiomyoma.
Methods: Uterine interstitial and submucosal leiomyomas were observed in a total of 143 patients between 2014 and 2016. The factors compared between women who underwent myomectomy (surgical group) and women who did not (non-surgical group) were age at clinic visit, body mass index, previous pregnancy history, number of leiomyomas, maximum leiomyoma diameter, follicle stimulating hormone level on day 3 of the menstrual cycle, presence of male factors, fallopian tube factors, previous myomectomy, and assisted reproductive technology. The correlation of the abovementioned factors with chemical pregnancy was investigated by statistical analysis.
Results: Pregnancy rate in the surgical and non-surgical group was 63.0% and 39.3%, respectively, with significant difference in pregnancy rate observed based on history of myomectomy (p=0.006). Multivariate analysis using Cox’s proportional hazards model showed number of leiomyomas and fallopian tube factors were related factors and no correlation with history of myomectomy was observed. The median time until chemical pregnancy was not significantly different between the groups, at 377 days in the surgical group and 419 days in the non-surgical group (p=0.706).
Conclusion: This retrospective observational study did not clarify the usefulness of uterine myomectomy in the management of patients with infertility presenting with uterine leiomyoma. However, approximately 50% of women who underwent uterine myomectomy for submucosal or interstitial leiomyomas that were either ≥ 4 cm in size or were ≥ 4 in number might become pregnant approximately 1 year postoperatively.
Uterine leiomyomas, Uterine myomectomy, Infertile, Pregnancy, Intrapartum hemorrhage volume
Yoshida M, Miyake T. The Outcomes of Uterine Myomectomy in Infertile Patients with Uterine Leiomyomas. Ann Infert Rep Endocrin. 2019;2(1):1014.