Ann Infertil Reprod Endocrinol | Volume 2, Issue 1 | Research Article | Open Access
Seda Karabulut1,2*, Pelin Kutlu3, Oya Korkmaz1,2 and İlknur Keskin1,2
1Istanbul Medipol University, School of Medicine, Turkey
2Istanbul Medipol University, REMER (Regenerative and Restorative Medicine Research Center), Turkey
3Medicana Çamlıca Hospital IVF Center, Turkey
*Correspondance to: Seda Karabulut
Fulltext PDFIntroduction: Effects of low oxygen versus atmospheric oxygen have been the subject of many studies. Oxygen concentration is suggested to be correlated with reactive oxygen species production hence effect early embryo development.
Aim: The aim of our prospective randomized study was to investigate the effects of different oxygen concentrations (5% versus atmospheric oxygen) on the ICSI outcome parameters including fertilization, early embryo development, embryo quality, and pregnancy and implantation outcomes.
Materials and Methods: This is a prospective randomized trial that included 2682 couples who attend for ICSI treatment in IVF center of Medicana Camlica Hospital. Embryos were incubated either in a low O2 concentration (5%) or ambient atmosphere concentration (~21%). The outcome parameters were analyzed and compared between two groups.
Results: None of the ICSI outcome parameters were affected significantly from the oxygen concentration although all parameters especially the top quality embryo rate was increased in 5% oxygen concentration.
Conclusion: It may be concluded that it is the metabolic state of an embryo that decide to use the oxygen, not the oxygen concentration it is exposed to.
Karabulut S, Kutlu P, Korkmaz O, Keskin İ. No Benefit of Reduced Oxygen Level for the Culture of Human Embryos In Vitro. Ann Infert Rep Endocrin. 2019;2(1):1013.