Amidyala Lingaiah1, VCS Srinivasarao Bandaru2*
1Director of Medical Services, Yashoda Group of Hospitals, India 2Department of Neurology & Clinical Research, Yashoda Group of Hospitals, IndiaFulltext PDF
Background: The COVID-19 infection affects all age groups and both genders. Recent studies have suggested that elder subjects are more prone to COVID-19 infection and its complications compared to young and middle-aged subjects. To investigate COVID-19 infection affecting patients with different age groups (young age, middle age and elder age) with biomarkers. Methods: Data was collected retrospectively from Yashoda Hospital Hyderabad, and study period from April 2020 to October 2020. Results: Out of 115 patients, men were 83 (72.3%) mean age was 55.7 ± 14.5 years (age range 18 to 89 years) mean duration of hospital stay was 10.9 ± 6.0 days (stay in hospital range 6 to 29 days). Hypertension was seen in 24 (20.8%), diabetes in 12 (10.4%), previous history of cardiovascular disease in 11 (9.5%) and previous history of cerebrovascular disease in 6 (5.2%). Mechanical ventilator support was required in 21 (18.2%), lung area affected on CT chest appearance was less than 25% in 50 (43%), 25% to 49% in 35 (30.4%), ≥ 50% in 30 (26%). Mean C-Reactive Protein (CRP) value was 68.7 ± 18.6 mg/L, mean D-dimer 1471.8 ± 591.4 ng/ml, mean procalcitonin 1787.1 ± 550.8 ng/ml, mean interleukin-6 was 11.4 ± 3.8pg/ml and mean serum ferritin was 428 ± 167.9 ng/ml. Among the age groups, 17.3% were young, 38.2% were middle aged and 44.3% were elderly and the overall mortality was 4.3%. The elder age group was significantly associated with longer mean duration of hospital (p=0.02), higher mean CRP value (p=0.006), mean D-dimer value (p<0.0001), mean procalcitonin (p<0.001), mean interleukin-6 (p=0.001), mean serum ferritin (p=0.001) values compared to young and middle age patients. Conclusion: Our study found elder age group constituted 44.3% of COVID-19 infected patients and inflammatory markers CRP, D-dimer, procalcitonin, interleukin-6 and serum ferritin levels were significantly higher in them.
Elder age; CRP; Procalcitonin serum ferritin; D-dimer serum ferritin; COVID-19 infection
Lingaiah A, Srinivasarao Bandaru VCS. Role of Biomarker in COVID-19: A Study from Tertiary Care Center. Ann Infect Dis Epidemiol. 2021; 6(1): 1062.