Ann Infect Dis Epidemiol | Volume 4, Issue 1 | Case Report | Open Access

Clinical Results of Lipopolysaccharide Filter Use in Sepsis Developed After Liver Transplantation: Report of Two Cases

Emrah Otan^*, Ertugrul Karabulut, Mahmut Burak Kilci, Volkan Ince, Cemalettin Koc, Cemalettin Aydin and Sezai Yilmaz

Department of of General Surgery, Inonu University School of Medicine, Turkey

^*Correspondance to: Emrah Otan 

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Abstract

Background and Case
Presentation: Sepsis remains as a preventable cause of mortality in ICU inpatients. Lipopolysaccharide (LPS) is the endotoxin, a structural component of the cell wall of gram-negative bacteria. Its release in systemic circulation results in the release of a group of inflammatory mediators, leading to initialization and/or exacerbation of sepsis. We report two cases with a history of Liver Transplantation (LT) cases that underwent LPS filter treatment with a diagnosis of Gram-negative related septic episode and discuss the related literature. Conclusions: Our cases demonstrate that LPS filters have significant and accountable effect on prognosis in treatment of sepsis. Further studies would be promising to clarify mechanisms and effectivity profiles of these techniques to provide better treatment algorhytms.

Keywords:

Sepsis; Lipopolysaccharide; Lipopolysaccharide filter

Citation:

Otan E, Karabulut E, Burak Kilci M, Ince V, Koc C, Aydin C, et al. Clinical Results of Lipopolysaccharide Filter Use in Sepsis Developed After Liver Transplantation: Report of Two Cases. Ann Infect Dis Epidemiol. 2019;4(1):1038.