Melvin Nova Gunawanto Barus1*, Syafruddin Ilyas2, Makmur Sitepu1 and Adang Bachtiar3
1Department of Obstetrics and Gynecology, University of North Sumatera, Indonesia 2Department of Biology, University of North Sumatera, Indonesia 3Department of Health Administration and Policy, University of Indonesia, IndonesiaFulltext PDF
Introduction: To determine the effect of andaliman fruit (Zanthoxylum acanthopodium DC) on the level of TNF-α, IL-6, blood pressure, Mean Arterial Pressure (MAP), and proteinuria in preeclampsia rat models. Material and Method: This is an experimental research using 24 laboratory rats (Rattus norvegicus) in Biology Laboratory at Faculty of Science, University of North Sumatera. Study subjects were female pregnant rat models (Rattus norvegicus sp) that were divided into 4 groups, such as negative Control (C-), positive Control (C+), andaliman extract 200 mg (C1), and andaliman extract 800 mg (C2). Treatment of all samples was carried out simultaneously and during the treatment, it was observed using the Post-test Only Control Group Design method. The examination results were analyzed by using SPSS 25. Results: Andaliman (Zanthoxylum acanthopodium DC) extract had been proven to reduce the level of TNF-α and IL-6 significantly in preeclampsia rat models (P<0.001). Blood pressure and MAP in treatment groups were significantly lower than control groups (p<0.001). Proteinuria was found in all K+, K1, and K2 rat models and shown recovery after 9 days since andaliman extract was given. Conclusion: This study proves the anti-inflammatory effect of andaliman extract (Zanthoxylum acantophodium DC), thus showing a decrease in the levels of proinflammatory cytokines TNF-α and IL6, lower blood pressure, MAP and better proteinuria output.
Andaliman; Zanthoxylum acantophodium DC; TNF-a; IL-6; Preeclampsia
Barus MNG, Ilyas S, Sitepu M, Bachtiar A. The Role of Andaliman Fruit (Zanthoxylum acanthoopodium DC) Extract on the Level of TNF-α, IL-6, Blood Pressure, Mean Arterial Pressure and Proteinuria in Preeclampsia Rat Models. Ann Gynecol Obstetr Res. 2020; 3(1): 1017.