Tomokatsu Hori1*, Hajime Miyata2 and Tatsunori Seki3
1Department of Neurosurgery, Tokyo Neurological Center Hospital, Japan
2Department of Neuropathology, Research Institute for Brain and Blood Vessels, Japan
3Department of Histology and Neuroanatomy, Tokyo Medical University, Japan
Purpose: ILAE task force proposed a simple histological classification of hippocampal sclerosis. Surgical results based on this classification are presented, and significance of the presence of PSANCAM abnormal immature granule cells in dentate gyrusis discussed.
Methods: 41 surgical specimens are analyzed and demographic data and MRI data are carefully analyzed in terms of ILAE HS classification system. PSA-NCAM immature neurons are examined in resected hippocampus.
Results: Type 1 HS is found in 25 patients (61%). (1) types of HS doesn’t correlate with age at operation and duration of illness, suggesting that these types represent distinct pathology of MTLE, (2) the mean age of onset in patients with type 1 sclerosis tends to be younger than those at least with no HS but this is not statistically significant (Kruskal-Wallis test), (3) the history of initial precipitating injury is not correlated with histological subtypes or post-operative seizure outcome, and (4) type 1 sclerosis seems to correlate with better postsurgical seizure outcome than other types. The choice of the operative procedure is important factor affecting the seizure outcome and that lateral temporal structure is also involved in the epileptogenesis in a subset of patients with MTLE. In fact, SAH alone is effective in over 80% of patients with type 1 sclerosis (Fisher’s exact test, p<0.05) but not for patients with type 3 sclerosis. Significance: The remarkable feature of our study is the presence of bizarre immature PSA-NCAM positive neurons in HS type 1 hippocampus. This neuron has a peculiar irregular soma with abundant neurites and synapses. The absence of bona fide astrocytes, presence of abnormal PSANCAM immature neurons might be neuron-glia abnormality causing long lasting intractable TLE.
Dentate granule cells; Amygdalohippocampectomy; Temporal lobectomy; Neuronglia abnormality; PSA-NCAM neurons 3; ILAE HS type; PSA; NCAM; Temporal lobe epilepsy
Hori T, Miyata H, Seki T. Surgical Results of Temporal Lobe Epilepsy Based on ILAE Hippocampal Sclerosis Classification and Abnormal Immature Granule Cells are Specific to Hippocampal Sclerosis Type 1. Ann Epilepsy Seizure. 2018; 1(1): 1006.