Melanie Copenhaver1 , Chack-Yung Yu2 and Robert P Hoffman1*
1Department of Pediatrics, Nationwide Children’s Hospital, USA2The Research Institute at Nationwide Children’s Hospital, USAFulltext PDF
The complement system is part of the innate immune system and plays a role in regulating inflammation. Increased inflammation is engaged in the development of adult cardiometabolic diseases such as insulin resistance, dyslipidemia, atherosclerosis, and hypertension. Adipose tissue not only produces complement but is also a potential target for complement activity. Obese adults and adults with cardiometabolic disease who are not obese have been shown to have increased complement levels. If not regulated appropriately, activated complement components have the potential to harm the host. Here we review complement physiology, complement genetics and its association to metabolic syndrome.
Copenhaver M, Yu C-Y, Hoffman RP. Complement C3 and C4 and Metabolic Syndrome. Ann Diabetes Res. 2017; 1(1): 1003. .