Ojo OO*, Ajayi OO and Adewole M
Department of Biochemistry, Ekiti- State University Ado-Ekiti, NigeriaFulltext PDF
Flubendazole, a common anti-parasitic drug, is clinically used in the treatment of intestinal infections. Recently, reports confirmed its anti-cancer properties. Quercetin on the other hand, has been reported to inhibit the oxidation of other molecules and hence is classified as an antioxidant. This study therefore investigated the possible testicular impairment of Flubendazole and role of apoptosis as well as the ameliorating effect of co-administration of onion extract and quercetin. Groups I, II & III were treated with vehicle (control), 10 mg/kg quercetin and 10 mg/kg onion extract respectively. 5 mg/kg, 10 mg/kg and 20 mg/kg doses of flubendazole were administered to mice in group IV, V and VI respectively. Groups VII and VIII were treated with 20 mg/kg/bwt FB+10 mg/ kg quercetin and 20 mg/kg/bwt FB + 10 mg/kg onion extract respectively. FB was administered intraperitoneally and consecutively for 14 days. Results showed that FB caused significant elevation of ROS and MDA levels whereas levels of SOD and GSH were reduced significantly in mice testes. Sperm head count and motility was significantly decreased with simultaneous decrease of sperm morphology by flubendazole treatment at doses of 10 mg/kg/bwt and 20 mg/kg/bwt. Flubendazole also led to compromise in sperm DNA integrity. Increased activities of Caspases 3 and 9 indicate that apoptosis were induced by flubendazole in the rats. However, co-administration with onion extract served to reverse these toxic effects of FB.
Flubendazole; Onion extract; Quercetin; Apoptosis; DNA Integrity
Ojo OO, Ajayi OO, Adewole M. Utility of Allium cepa (Onion) Extract in Flubendazole - Testicular Dysfunction. Ann Clin Toxicol. 2021; 4(1): 1034.