Ann Clin Toxicol | Volume 2, Issue 2 | Research Article | Open Access
Okediran BS*, Suleiman KY, Adah AS and Sanusi F
Department of Veterinary Physiology and Biochemistry, University of Ilorin, Nigeria
*Correspondance to: Okediran BS
Fulltext PDFLead is one of the main environmental contaminants which can threaten the living organisms in many ways. Lead toxicity is associated with a number of physiological, hematological and biochemical alterations. The study aimed to investigate mitigation of lead acetate induced toxicity by ginger (Zingiber officinale) on the risk which may result from intraperitoneal exposure to dose of lead acetate on hematological indices, function of liver and kidney. The experiment was performed on twenty male rats. They were maintained on standard healthy laboratory conditions and had free access to food and drinking water ad libitum. The rats were divided into four equal groups A-D. The group A represented the healthy control rats, while groups B, C, and D were administered doses of lead acetate alone (intraperitoneally), ginger alone (orally), and combination of lead acetate with ginger (intraperitoneally and orally) respectively for 2 weeks. At the end of the experimental period, blood was collected for hematological studies while serum was used for biochemical analysis. The results indicated that rats treated with lead acetate alone showed significant reduction in TEC, PCV, MCV, MCH and MCHC compared to the healthy control ones while there was significant elevation in TLC. These was also showed significant increase in the activities of ALT, AST as well as marked hypoproteinemia, hypoalbuminemia and azotaemia indicating liver and kidney dysfunction. However upon mitigation with Zingiber officinale (group D) the results showed that it was able to reverse the decrease PCV, MCV, MCH, MCHC, RBC counts as well as reduce the white cell count compared to group B that was exposed to lead acetate alone. The azotaemia, hypoproteinemia, hypoaluminemia and activities of AST and ALT were also reversed. The study revealed that Zingiber officinale is capable of mitigating lead acetate induced toxicity which is due to it antioxidant potential.
Blood; kidney; lead; liver; Zingiber officinale
Okediran BS, Suleiman KY, Adah AS, Sanusi F. Mitigation of Lead Acetate Induced Toxicity by Ginger (Zingiber officinale). Ann Clin Toxicol. 2019; 2(2): 1020.