Ann Clin Toxicol | Volume 2, Issue 2 | Short Communication | Open Access

Self Injurious Behavior Observed after Administration of Poly herbal Combination for the Management of Antidepressant in Albino Rat

Harikesh Maurya^1* and Anjali Gupta²

¹Department of Pharmacy, M.G.B. Rajat College of Pharmacy and Management, India
²Department of Pharmacy, Hygia Institute of Pharmaceutical Education and Research, India

^*Correspondance to: Harikesh Maurya, 

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Abstract

Self-Injurious Behavior (SIB) is the behavior of individuals who impose physical damage conceivably pain, leading themselves that highly established in autism and other neuro-developmental disorders. We have investigated the antidepressant activity of polyherbal combination using leadinduced depressant in the rat model. The rats were administered with lead acetate once daily for seven days, and vulnerability for lead-induced depressant was evaluated. Then the rat was treated with a polyherbal combination of Camellia sinensis and Boerhavia diffusa at a dose of 200 mg/kg, particularly one rat developed hyperactivity, long duration of self-injurious behaviors like licking and cutting own limbs observed at the 22nd day of treatment. Over the day rat was die and the brain removed for histopathological examination. The finding suggests that the combination of Camellia sinensis and Boerhavia diffusa may contribute to the expression of SIB, and specify that further investigation is defensible.

Keywords:

Self-injurious behavior; Depressant; Camellia sinensis; Boerhavia diffusa

Citation:

Maurya H, Gupta A. Self Injurious Behavior Observed after Administration of Poly herbal Combination for the Management of Antidepressant in Albino Rat. Ann Clin Toxicol. 2019; 2(2): 1019..