Ann Clin Toxicol | Volume 2, Issue 1 | Short Communication | Open Access
Bhattacharya S and Akhter F
Fulltext PDFIt is currently believed that estrogen and progesterone both the steroid hormones antagonize each other in the prevention of breast cancer. Many investigators on the other hand reported that the presence of both the steroid hormone receptor is a good prognostic indicator of breast cancer. Both estrogen and progesterone receptors are essentially important in the prevention of breast cancer through the synthesis of maspin an anti-breast cancer protein by the hormone receptor induced Nitric Oxide (NO) production. Both the breast cancer tissue and neutrophil were found to synthesize maspin, and both the steroid hormone stimulates maspin synthesis by binding with their corresponding receptor which ultimately activate the homologous DNA sequence in the nucleus. It was concluded that both estrogen and progesterone are complementary with each other in NO induced maspin synthesis to prevent breast cancer malignancy
Estrogen; Progesterone; Nitric oxide; Breast cancer
Bhattacharya S, Akhter F. Steroid Hormone Receptors Expression and Breast Cancer Management. Ann Clin Toxicol. 2019; 2(1): 1015.