Ann Clin Pharmacol Ther | Volume 1, Issue 1 | Review Article | Open Access

A Review of Α-Glucosidase and Α-Amylase Inhibitors for Type 2 Diabetes Isolated From Some Important Indian Medicinal Plants

Rahul L Gajbhiye, Anand Ganapathy and Parasuraman Jaisankar*

Department of Organic and Medicinal Chemistry, CSIR, Indian Institute of Chemical Biology, India

*Correspondance to: Parasuraman Jaisankar 

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Abstract

α-Glucosidase and α-Amylase are the key enzymes involved in the digestion of the carbohydrate. Inhibitors of these enzymes can slow down the liberation of absorbable monosaccharides from dietary complex carbohydrates and is considered a strategy for the treatment of disorders in carbohydrate uptake, such as diabetes and obesity, as well as, dental caries and periodontal diseases. In the Indian context, the traditional system of medicines especially “Ayurveda” describes the use of medicinal plant, for primary health care and treatment of various diseases including diabetes mellitus, in various forms. Several contributions have been made to establish the anti-diabetic potential of plant extracts or isolated constituents from Indian medicinal plants, but so far only a few species have been explored to isolate and identify the constituents with α-glucosidase and α-amylase inhibitory potential. This review found a total of twenty seven species belonging to twenty four genuses of Indian medicinal plants which have been screened so far leading to the identification of fifty eight compounds with potential to inhibit the two enzymes. These constituents belong to flavones, flavone glycosides, triterpenes, alkaloids, tannins and other polyphenolic compounds, as is usually found in such investigations.

Keywords:

α-Glucosidase; α-Amylase; Inhibitors; Type 2 diabetes; Indian medicinal plants; Ayurveda

Citation:

Gajbhiye RL, Ganapathy A, Jaisankar P. A Review of Α-Glucosidase and Α-Amylase Inhibitors for Type 2 Diabetes Isolated From Some Important Indian Medicinal Plants. Ann Clin Pharmacol Ther. 2018; 1(1): 1003.

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