Ann Clin Med Res | Volume 3, Issue 1 | Mini Review | Open Access
Novy Gupte* and Sapna Pradhan
Department of Pharmacology, Army College of Medical Sciences, New Delhi, India
*Correspondance to: Novy Gupte
Fulltext PDFBackground: Antibiotic-Resistant (ABR) infections pose a serious challenge worldwide. The medical profession is in doldrum on account of its failure to successfully treat a large proportion of cases suffering from serious infections, resulting in considerable morbidity and mortality. The uncontrolled pandemic of COVID-19 has contributed to escalation of such infections, thereby adding fuel to fire. Objective: To provide a state-of-the-art detail about the dynamics underlying the ABR infections. Design: Review of the English medical literature concerning dynamics of ABR infections. Salient Features: ABR may be natural or acquired and its transmission vertical or horizontal. It may be mono, poly, multi, extensive or even pan drug resistance. The mechanisms involved are resistance to entry of the antibiotic at cell membrane level, modification of target, activation of destructive enzymes against antibiotic and rapid exit of the antibiotic. Though there is a long list of World Health Organization prioritized bacterial pathogens, the acronym, ESCAPE, highlights the most important causative pathogens. Research is needed to explore additional mechanism(s) if any. Conclusion: A good understanding of the dynamics of antibiotic resistant infections is mandatory to carry forward further work in the field and for intensifying strategies to prevent and control infectious diseases and antibiotic resistance, developing novel antibiotics and alternative and complementary pharmacotherapeutic strategies
Antibiotic misuse; Antibiotic resistance; COVID-19; Multidrug resistance; Novel antibiotics
Gupte N, Pradhan S. Antibiotic- Resistant Infections: Understanding the Dynamics. Ann Clin Med Res. 2022; 3(1): 1057.