Ann Clin Med Res | Volume 2, Issue 6 | Research Article | Open Access

Peripheral Calcification and Coronary Artery Disease

Eileen Reilly1 *, Balamurugan Pandiyan2 and Michael Bolan

1 University of Wisconsin School of Medicine and Public Health, USA 2 Department of Mathematics, University of Wisconsin Whitewater, USA

*Correspondance to: Eileen Reilly 

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Objective: Determine whether presence of peripheral calcification on lower extremity roentgenogram correlates with current diagnosis of Coronary Artery Disease (CAD). Methods: 2000 plain films between January 2018 to October 2018 of lower extremities reviewed for presence of calcification in women and men ages 50 to 75 (Part A). Case subjects matched by age and gender with control subjects. Past medical history investigated for current diagnosis CAD. Data analyzed and then additional 2000 plain film entries reviewed of both genders 65 to 75 years old (Part B). Low case numbers in Part A, 50 to 64 y/o females and males, therefore Part B included both genders ages 65 to 75. Odds Ratio (OR), Confidence Interval (CI) and p-value computed. Results: Part A =400 + Part B =464 subjects. Low yield case subjects in the 50 to 59 bracket for females and males therefore low powered. Peripheral calcification present in males in the 60 to 69 (65% and 87%) with OR 2.31. Females 60 to 69 y/o had OR of 2.23 respectively. Of males in the 70 to 75 y/o OR 4.78 and females 1.59. Part B results of 65 to 75 y/o females OR 1.82 and male results OR 2.73. P value was significant for males in Part A 70 to 75 y/o (0.002) and male 65 to 75 y/o in Part B (<0.001) with 95% CI of 1.52- 4.91. Conclusion: Presence of calcification on peripheral roentgenogram demonstrate significant odds ratio to known coronary artery disease in men 65 to 75 y/o.


Reilly E, Pandiyan B, Bolan M. Peripheral Calcification and Coronary Artery Disease. Ann Clin Med Res. 2021; 2(6): 1043..

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