Ann Clin Med Res | Volume 2, Issue 5 | Research Article | Open Access

Health-Related Quality of Life among Patients with Depression: A Systematic Review of Measure Development and Properties

Nkporbu AK1,2*, Ogaji DS1,3 and Nduka EC4

1 Department of Public Health, University of Port Harcourt, Nigeria 2 Department of Mental Health, University of Port Harcourt, Nigeria 3 African Centre for Public Health and Toxicological Research, University of Port Harcourt, Nigeria 4 Department of Mathematics Statistics, University of Port Harcourt, Nigeria

*Correspondance to: Nkporbu AK 

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Background: An increasing number of measures are being developed for assessing Health-Related Quality of Life (HRQOL) of patients with depression. The high level of variability of these measures and their suitability for practice settings in developing countries remain a concern. Aim: A systematic review of the development, contents and measurement properties of available measures for HRQOL among patients with depression. Design: A systematic review. Data sources: Systematic search for worldwide published literature from PubMed, MEDLINE, CINAHL Plus, EMBASE, and PsycINFO databases were conducted. Study eligibility criteria: Studies included in this review reported the development and validation of measures for health-related quality of patients with depression. Data extraction: Data was extracted with a template prepared in accordance with the review objectives. Template had article identifier, setting, context, developmental processes, contents (domains, items, and scales), potential utility, psychometric and measurement properties (reliability, validity, and acceptability) were extracted, and narrative reports were presented. Findings: The review found 20 studies reporting 6 different measures for the evaluation of HRQOL of patients with depression. Three (50%) of these questionnaires were developed in the USA and the remaining from Brazil, Sweden and Norway. No measure had been developed or validated in the continent of Africa. The majority were published after 1990 (83%), contained between 20 to 40 core items (44%) which were developed inductively (85%). The most reported measurement index was the Cronbach's alpha (74%) with only one study reporting positive predictive value and testretest reliability. The domains of 78% of these measures can potentially be used to evaluate major depression. Conclusion: The wholesome transfer and use of measures developed for HRQOL of depressed patients across cultural and practice setting may pose enormous difficulties if not locally validated. The limited application of some pf the existing measures in the Nigerian practice setting provides a justification for the validation of the most adjudged appropriate measure to affirm its measurement properties in this locality.


Health-Related Quality of life; HRQOL; Depression; Measures; Questionnaires; Nigeria


Nkporbu AK, Ogaji DS, Nduka EC. Health-Related Quality of Life among Patients with Depression: A Systematic Review of Measure Development and Properties. Ann Clin Med Res. 2021; 2(5): 1039..

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