Ann Clin Immunol MicroBiol | Volume 1, Issue 2 | Research Article | Open Access

Profile of Antibacterial Resistance of the Enterobacteriaceae Family in Pediatric and Adult Patients

Filipe Antonio Mahaluca1,2*, Sabiha Essack3, Tomas Zimba4 and Jahit Sacarlal

1Higher Institute of Health Sciences (ISCISA), Mozambique 2Higher Institute of Accounting and Audit of Mozambique (ISCAM), Mozambique 3University of KwaZulu-Natal, South Africa 4Maputo Central Hospital (HCM), Mozambique 5Faculty of Medicine, Eduardo Mondlane University, Mozambique

*Correspondance to: Filipe Antonio Mahaluc 

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Background: Bacterial infections are the main cause of hospitalization, with those associated with health care caused by gram-negative bacteria the most frequent. Many of the most serious and difficult infections to treat occur in the Intensive and Intermediate Care Units, not only because it is where patients with serious infections are hospitalized but also because of the intensive use of antibiotics. Objective: To describe the antibacterial resistance profile of Enterobacteriaceae in adults and pediatric patients at Central Hospital of Maputo. Methods: This is a cross-sectional, epidemiological, quantitative approach, with a retrospective analysis of secondary data in the Bacteriology sector of the HCM Microbiology Laboratory of samples analyzed in 2017. Results: In Pediatrics, Enterobacteriaceae accounted for 37.8% (48/127) of all infections, with Klebsiella pneumoniae (43%) being the most prevalent. In adults, Enterobacteriaceae accounted for 51.9% (27/52) of all infections, with Klebsiella spp (26%), Escherichia coli (22%) and Klebsiella oxytoca (19%) being the most prevalent. In pediatrics, Enterobacter cloacae (87%) and Enterobacter agglomerans (76.5%) and Klebsiela spp. (69.2%) had high resistance proportions. In the Adults the highest percentage of resistance was recorded in Enterobacter spp. (71.4%), Klebsiella oxytoca (60.5%) and Escherichia coli (56.4%). The mean resistance rate between the two sectors was 59.4%, 64% in Pediatrics and 52.4% in Adults, and this difference is significant. Conclusion: Inadequate prescribing and impure treatment with cephalosporins may have been one of the factors that aided the emergence of third generation cephalosporin resistant Enterobacteriaceae isolates, as well as the high prescription of carbapenems could be related to the expressive number of imipenem resistant Escherichia coli. Patients infected with strains of Enterobacter species should receive a differentiated treatment for the remaining patients, as the high resistance rates recorded show the exhaustion of the therapeutic treatment in a wide range of antibacterial agents.  


Enterobacteriaceae; Antibacterial Resistance; Mozambique


Mahaluca FA, Essack S, Zimba T, Sacarlal J. Profile of Antibacterial Resistance of the Enterobacteriaceae Family in Pediatric and Adult Patients. Ann Clin Immunol Microbiol. 2019;1(2):1007..

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