Ann Clin Case Rep | Volume 6, Issue 1 | Case Report | Open Access

Diagnostic Value of Serum Amyloid A (SAA) in Assessing the Occurrence of Acute Phase Reaction in Athletes

Konrad Witek1*, Justyna Zaborowska2, Dariusz Turowski1 and Sylwia Lewandowska-Pachecka2

1Department of Biochemistry, Institute of Sport-National Research Institute, Poland
2Division of Laboratory Medicine, Medical University of Warsaw, Poland

*Correspondance to: Konrad Witek 

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Introduction: The aim of this study was to assess the usefulness of Serum Amyloid A (SAA) measurement in determining the presence or intensity of acute phase reaction in athletes in relation to selected diagnostic indicators. Methods: Thirty male athletes from different sports disciplines participated in this study. Venous blood samples were collected in the morning, on an empty stomach and transferred to the laboratory within 1 h of collection. Concentrations of SAA, CRP hs, creatine kinase were measured in serum. Hematological indicators were measured in whole blood. Results: In the study group there were found statistically significant positive relationship between SAA protein concentrations with CRP hs levels. Correlations between SAA concentration and some of the hematological indicators were also observed. SAA positively correlated with the percentage and count of neutrophils and monocytes, whereas the relationship with the percentage and count of lymphocytes was negative. Among the subjects there were no statistically significant correlations between serum Amyloid A concentration and CK activity. There were also observed lack of correlation between SAA concentration and White Blood Cells Count (WBC), Hematocrit (HCT) and the percentage and count of Eosinophils (EOS), Basophils (BASO) and Immature Granulocytes (IG). Conclusion: The observed changes in the concentration of SAA does not permit clear identification of its advantages over widely used CRP measurements in the assessment of acute phase response occurrence in athletes. However, it appears that SAA could be an earlier indicator of acute phase response, but that requires more research.


Serum Amyloid A; CRP; Acute phase reaction; Inflammation; Physical exercise; Athlete


Witek K, Zaborowska J, Turowski D, Lewandowska-Pachecka S. Diagnostic Value of Serum Amyloid A (SAA) in Assessing the Occurrence of Acute Phase Reaction in Athletes. Ann Clin Case Rep. 2021; 6: 2030..

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