Behnam Rabiee1,2*, Muhamad Festok1,2, Michael Gaspari1,2, Ali Chaudhry1,2 and Aaila Chaudhry1,2
1Department of Ophthalmology, Nazareth Hospital, Philadelphia, PA, USA
2IC Laser Eye Care, Bensalem, PA, USA
Vitiligo is a chronic depigmenting skin disease with a major impact on quality of life, especially in young patients. The disease is autoimmune in nature, and the mainstay of treatment is based on immunosuppression with or without phototherapy. The roles of oxidative stress and dysbiosis have been established in the pathogenesis as well. In this report, we present a case of a 13-year-old male with new-onset periorbital vitiligo. A combination of topical tacrolimus plus an antioxidative and probiotic regimen could reach a complete repigmentation after 6 weeks. To date, no relapse has been noted after 52 weeks. The time to achieve repigmentation in this case was relatively lower compared to studies on tacrolimus monotherapy, which is the current first-line recommendation for facial vitiligo (although not officially approved). This report could highlight the potential of adjuvant therapy with antioxidants and probiotics to achieve an earlier, effective, and sustained response.
Rabiee B, Festok M, Gaspari M, Chaudhry A, Chaudhry A. Combination of Topical Tacrolimus, Antioxidants, and Probiotics in the Treatment of Periorbital Vitiligo. Ann Clin Case Rep. 2021; 6: 2027.