Ann Clin Case Rep | Volume 6, Issue 1 | Case Report | Open Access

Recurrent Myocarditis after the First Dose of SARS-CoV-2 mRNA-1273 Vaccine

Giuseppe Di Tano*, Luigi Moschini, Elva V Calvaruso and Gian Battista Danzi

Department of Cardiology, Ospedale di Cremona, Italy

*Correspondance to: Giuseppe Di Tano 

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Background: Several cases of myocarditis associated with COVID-19 mRNA vaccines have recently been reported in which the mechanism of vaccine-induced myocarditis has not been clearly identified. Case Report: We describe the case of a 29-year-old man who had an episode of recurrent acute myocarditis (confirmed by cardiac magnetic resonance) six days after he received the first dose of SARS-CoV-2 mRNA-1273 vaccine. The causal nature of this recurrent myocarditis remains elusive, but the event appears to be very peculiar as it occurred after the first dose of SARS-CoV-2 vaccine in a subject with a history of previously healed myocarditis. Conclusion: This case raises practical questions concerning the risk/benefit ratio of SARS-CoV-2 prophylactic vaccination in young people, especially in those with a history of myocardial or pericardial inflammatory disease.


SARS-CoV-2 vaccine; Myocarditis; Cardiac magnetic resonance


Di Tano G, Moschini L, Calvaruso EV, Danzi GB. Recurrent Myocarditis after the First Dose of SARS-CoV-2 mRNA- 1273 Vaccine. Ann Clin Case Rep. 2021; 6: 2018..

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