Li Yang1, Ting Wang1, Wei Cheng2, Youde Cao3 and Shuliang Guo1*
1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, China 2The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, China 3Department of Pathology, Chongqing Medical University, ChinaFulltext PDF
A 62 years man was accidentally detected multiply GGN nodules and didn’t do any following up examination. After suffering from a serious low back pain, he was diagnosed as right lung adenocarcinoma with metastases of hilar and mediastina lymph nodes, bilateral lungs, liver and multiple bones, IV stage, EGFR/ALK(-), STK11(+), MDM4(+). Because of intolerant to chemotherapy and other ways, he eventually died of respiratory failure in four months after confirmed diagnosis with total process was 39 months. Whether the rapid growth of mGGN is associated with hyper-progress mutations in KRAS combined with STK11 and MDM4 remains to be further studied urgently. According to the management guideline of Ground Glass Nodule (GGN), regularly repeated CT scan is extremely important to achieve early detection, diagnosis and treatment for lung cancer.
Yang L, Wang T, Cheng W, Cao Y, Guo S. Partial Ground Glass Nodule with Irregular Following-up “Rapidly” Progressed to Refractory Advanced Lung Cancer: A Case Report. Ann Clin Case Rep. 2021; 6: 2004..