Ann Clin Case Rep | Volume 6, Issue 1 | Case Report | Open Access

Is JAK2-Mutation Associated with Extensive Clot Burden in Cerebral Venous Thrombosis?

Carmela Sales1*, Tissa Wijeratne1,2,3 and Josephine Anne Lucero4

1Department of Neurology, AIMSS, Sunshine Hospital and Melbourne Medical School, Victoria, Australia 2School of Public health and Psychology, La Trobe University, Victoria, Australia 3Department of Medicine, Rajarata University, Anuradhapura, Sri Lanka 4Department of Medicine, University of the Philippines- Philippine General Hospital, Philippines

*Correspondance to: Carmela Sales 

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Abstract

Cerebral Venous Thrombosis (CVT) is a, rare form of stroke which is usually associated with acquired and genetic risk factors. The presence of JAK2 or JAK2‐V617F mutation is a novel genetic biomarker increasing which has been shown to increase the risk of arterial and venous thrombosis, especially in patients with myeloproliferative disease. We present a case of a patient with extensive CVT affecting intracranial venous sinuses and extending to the neck vessels and possible JAK2 associated polycythemia vera who had a good therapeutic response to a direct oral anticoagulant.

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Citation:

Sales C, Wijeratne T, Anne Lucero J. Is JAK2-Mutation Associated with Extensive Clot Burden in Cerebral Venous Thrombosis?. Ann Clin Case Rep. 2021; 6: 1911..

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