Vipul Sanghavi1 , Nadiya Sultana2 , Ningyu Chai2* and Ghazanfar Ali Anwar2
1Department of Nephrology, Wexham Park Hospital, UK 2Department of Gastroenterology, Wexham Park Hospital, UKFulltext PDF
Background: Eosinophilic Colitis (EC) is the least well- understood subgroup of the Primary Eosinophilic Gastrointestinal Diseases (EGIDs), a spectrum of disorders characterized by pathologic eosinophilic infiltration along the gastrointestinal tract, in the absence of other causes of eosinophilia. It is currently regarded as a diagnosis of exclusion. Case Presentation: This is a case report of EC, where a 47-year-old gentleman presented with chronic diarrhoea, mild abdominal pain, weight loss and intermittent right forearm swelling. Significant eosinophilia (7.63%) was identified and colonic biopsy demonstrated focal superficial active inflammation with markedly increased eosinophilic infiltration in the lamina propria. The work up for hyper-eosinophilia was otherwise negative. Once oral corticosteroids were initiated, his symptoms and eosinophil count improved. Conclusion: The scarcity of the reporting for EC could be due to its under-diagnosis. We suggest that all cases of chronic diarrhea should be offered colonoscopy with multiple biopsies to rule out the possibility of EC. A number of immunomodulatory agents and biologic agents are thought to hold promise for the treatment of EC. Due to its undefined pathophysiology, diagnostic thresholds and codified treatment guidelines, further studies involving large sample sizes of patients are required to understand its immunopathophysiology, in order to define optimum management strategies.
Eosinophilic; Eosinophilic gastrointestinal diseases; Corticosteroids
Sanghavi V, Sultana N, Chai N, Ali Anwar G. A Rare Case of Eosinophilic Colitis. Ann Clin Case Rep. 2020; 5: 1840.