Yingling Zu, Jian Zhou*, Yanli Zhang, Fengkuan Yu, Huifang Zhao, Ruirui Gui, Zhen Li and Yongping Song*
Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University, ChinaFulltext PDF
Anaplastic Large Cell Lymphoma (ALCL) is a rare type of malignant lymphoid disease with poor prognosis, especially ALK-ALCL. We evaluated the effectiveness and safety of Compound Realgar Natural Indigo Tablets (CRNIT) for a relapsed patient with ALK-ALCL after autologous Hematopoietic Stem Cell Transplantation (auto-HSCT). The patient was diagnosed with pathology of right inguinal lymph node enlargement. Partial Remission (PR) was achieved after two cycles of CHOP chemotherapy, and the patient had Stable Disease (SD) after sequential four cycles of CHOP chemotherapy, followed by achieved to Complete Remission (CR) one after local radiotherapy. Two months later, the patient experienced her first relapse and only achieved PR after four cycles of GDP chemotherapy. CR2 was achieved by auto-HSCT. The patient underwent the second relapse of disease at five months after auto-HSCT, manifesting as enlarged left inguinal and abdominal lymph nodes. Chidamide displayed transient curative effect accompanied by the grade of III myelosuppression. Large sheet-like red papule were gradually present throughout double lower limbs and the left lateral thigh. The CRNIT at 1.35 g was given orally three times daily. Efficacy was obvious and without severe adverse reactions especially in term of papule, lasting thirteen months. Finally, the patient died of pulmonary infection due to myelosuppression after chemotherapy. Even so, the CRNIT is a feasible therapy for relapsed patient with ALK-ALCL to buy time for more effective means and avoid side effects of chemotherapy.
Zu Y, Zhou J, Zhang Y, Yu F, Zhao H, Gui R, et al. Relapsed Anaplastic ALK-Large Cell Lymphoma after Autologous Hematopoietic Stem Cell Transplantation Experiences Compound Realgar Natural Indigo Tablets: A Case Report. Ann Clin Case Rep. 2020; 5: 1825.