Sasirekha Rengaraj1*, Sutharsika Thiyagalingam1, Vimala Kathirvel1 and Dillikumar2
1Department of Obstetrics and Gynaecology, Jawaharlal Institute of Postgraduate Medical Education and Research, India
2Department of Paediatrics and Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research, India
Hexokinase mutation (MODY-2) is frequently misdiagnosed as either type I or type II diabetes mellitus especially if presented for the first time during pregnancy. Generally MODY affects 1% to 2% of diabetes. The defect in glucose sensing mechanism in MODY-2 results in higher set point for maintenance of glucose homeostasis. Treatment is not recommended outside the pregnancy however in pregnancy fetal abdominal circumference helps to decide about the insulin requirement. We are presenting a case in which MODY 2 was diagnosed for the first time after her first pregnancy, there were controversies around the first pregnancy and the second one was uneventful. Genetic testing is mandatory to establish the diagnosis. In addition to it, implications of MODY and its subtypes along with pattern of inheritance and management aspects have been discussed in detail.
Rengaraj S, Thiyagalingam S, Kathirvel V, Dillikumar. Raised Blood Glucose Due to Heterogeneous Glucokinase Gene Mutation (MODY 2) Diagnosed for the First Time in Pregnancy: The Dilemmas and Successful Management- Case Report and Review of Literature. Ann Clin Case Rep. 2019; 4: 1624.