Fan Ren1#, Honglin Zhao1#, Zihe Zhang1#, Hongbing Zhang1, Xiaoqian Xu2, Hongyu Liu1, Gang Chen1* and Jun Chen1*
1Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, China
2Health Management Center, Tianjin Medical University General Hospital, China
#These authors are equally contributed
Pulmonary Sclerosing Hemangioma (PSH) is a relatively rare lung tumor. Most studies suggest that PSH is benign, but some researchers suggest PSH have malignant potential due to company with lymph node metastasis in certain cases. Here, we reported a case of a 30-year-old female with a solitary mass in her left lung. After a left lower lobectomy and systemic lymphadenectomy was performed, the pathological diagnosis of pulmonary sclerosing hemangioma with lymph node metastasis was given. The immunohistochemistry demonstrated the positive expression of TTF1, EMA in the primary site and metastatic lymph node. Furthermore, AKT1 gene mutation was detected in primary tumor by next generation sequencing. The patient has shown no local recurrence or distal disease in a 1-year follow-up period.
Pulmonary sclerosing hemangioma; Lymph node metastasis; AKT1 mutation
Ren F, Zhao H, Zhang Z, Zhang H, Xu X, Liu H, et al. Pulmonary Sclerosing Hemangioma with Lymph Node Metastasis: A Case Report. Ann Clin Case Rep. 2019; 4: 1617.