Seyyed Hossein Hassanpour1*, Mohammad Amin Dehghani2, Seyyedeh Zeinab Karami3 and Fatemeh Dehghani4
1Department of Young Researchers and Elite Club, Yasooj Branch, Islamic Azad University, Iran
2Department of Toxicology, School of Pharmacy, Ahwaz Jundishapour University of Medical Sciences, Iran
3Department of Biology, Faculty of Basic Sciences, Yasouj University, Iran
4Department of Genetic, Faculty of Medicine, Shiraz University of Medical Sciences, Iran
Leukemia is a common reason of mortality in worldwide and useful therapeutic strategy is needed in order to its incidence. Induction of apoptosis can inhibit cell proliferation and compounds with this property are required for the treatment of leukemia. Considering the important issue that the rate of proliferation of cancer cells is high, thus mitochondrial dysfunction can abrogate their growth and ultimately reduce blood tumors. In this review study, we focus on compounds with anticancer activity, whose mechanism of their action is induction of apoptosis and mitochondrial dysfunction and also explain their effect on cancer cells. Our review showed that these compounds exhibit potential anti-leukemia activity after incubation in leukemia cell lines. Therefore; they are promising compounds to treat leukemia, however the need to evaluate their effects on normal cells in order to determine their toxicity.
Leukemia; Apoptosis; Mitochondria dysfunction; Proliferation
Hassanpour SH, Dehghani MA, Karami SZ, Dehghani F. Role of Apoptosis and Mitochondrial Dysfunction in the Treatment of Leukemia Types. Ann Blood Cancer. 2018; 1(1):1002.