Am J Pharmacol | Volume 4, Issue 1 | Mini Review | Open Access

Design, Synthesis, and Antimicrobial Evaluation of Novel1,3,5-Triazine Derivatives

Mangesh E Shelke^*

Department of Chemistry, Government Vidarbha Institute of Science and Humanities, India

^*Correspondance to: Mangesh E Shelke 

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Abstract

Innovative series of 1-phenyl-2-thio-(1H)-4-[(1-phenyl-2-thio-(1H)-4-amino-1,2-dihydro-s-triaz- 6-yl)]-amino-6-phenylamino-1,2-dihydro-1,3,5-triazine [4a (ii) to 4f (iv)] have been obtained by the isomerization of 2-phenylamino-4-[-(-4-amino-6-phenylimino-1,3,5-thiadiaz-2-yl)]-amino- 6-phenylimino-1,3,5-thiadiazine [3a (ii) to 3f (iv)] in presence of ethanolic sodium bicarbonate solution , which were prepared initially by the interaction of 1-formamidino-3-thioamido-Nphenylformamidino- thiocarbamide (1a) and phenyl isocyanide chlorides. The structures of all synthesized compounds were established with the aid of IR, PMR spectrum data and elemental analysis. The synthesized 1,3,5-triazine was analyzed for antimicrobial activities by cup plate diffusion method and exhibited a broad spectrum of antimicrobial activity against test pathogens and found that they show remarkable insecticidal and bactericidal properties.

Keywords:

Antimicrobial activity; Synthesis; 1,3,5-thiadiazines; 1,3,5-triazines

Citation:

Shelke ME. Design, Synthesis, and Antimicrobial Evaluation of Novel 1,3,5-Triazine Derivatives. Am J Pharmacol. 2021; 4(1): 1029.