Naveen Kumar, Poonam Singh, Govind Singh and Prabhakar Kumar Verma*
Department of Pharmaceutical Sciences, Maharshi Dayanand University, IndiaFulltext PDF
The hydroethanolic extracts of stem and root of Callistemon citrinus were evaluated for their antidiabetic, analgesic and antihypertensive potentials in Streptozotocin (STZ) induced diabetes in rats for 21 days. The effect of these extracts was also observed on biochemical and oxidative stress parameters (i.e. SOD level, GSH level, nitrite level, protein level) in STZ induced diabetes in rats after 21 days of treatment. In our in vitro studies results showed that hydroethanolic stem and root extract of Callistemon citrinus inhibit the alpha amylase enzyme in uncompetitive manner whereas inhibit alpha glucosidase enzyme in mixed manner. The results of in vivo studies showed that the hydroethanolic stem and root extract of callistemon citrinus at a dose of 400 mg/kg have antidiabetic and analgesic potential in STZ induced diabetes in rats. Also, there was increase in levels of protein, nitrite and glutathione; whereas there was decrease in SOD level as compared to that of STZ treated rats after 21 days of extract treatment.
Callistemon citrinus; Antidiabetic; Nitrite level; Streptozotocin
Kumar N, Singh P, Singh G, Verma PK. Evaluation of Pharmacological Potential of Stem and Root of Callistemon citrinus in STZ Induced Diabetes in Rats. Am J Pharmacol. 2020; 3(1): 1027.