Am J Pharmacol | Volume 2, Issue 3 | Research Article | Open Access
Nedra B1*, Maroua M1, Adrian F2, Horea M2, Tekaya WH3, Samira M1 and Leila T1
1Laboratory of Physiology, University of Tunis El Manar, Tunisia
2Department of Cell and Molecular Biology, Iuliu Hatieganu University of Medicine and Pharmacy, Romania
3Department of Stomatology, University of Monastir, Tunisia
The brain serves as the center of the nervous system. Physiologically, it centralized control over the other organs of the body and acts on the rest of the body both by generating patterns of muscle activity and by driving the secretion of hormones. In the present ultrastructural investigations, we undertake to figure out the subcellular impact of Lanthanum (La) on brain of Wistar rats after its intraperitoneal injection under soluble solution. Our data, using Transmission Electron Microscopy (TEM), attempted to locate that the administered element was selectively concentrated under insoluble form within the lysosome of nerve cells with their axons and oligodendrocytes from brain ultrathin sections of lanthanum treated rats. While, neither electron dense surcharge, nor ultrastructural modifications were identified in brain ultrathin sections from rats given intraperitoneal saline solution. In addition to the presence of lanthanum deposits in the nerve and oligodendrocytes cells, visible changes in tissue and cells such as histology one involving cytoplasmic vacuolization and rarefication, marked expansion of the endoplasmic reticulum and mitochondrial damages were also identified as consequences of the presence of lanthanum. Although during our experiments we found that there were cases of death weight loss and mother’s abortions. These results speculated the toxicity of lanthanum at the used dose. The observed signs of toxicity allowed concluding that the important role of lysosomes in the sequestration of this element under an insoluble form in all categories of cells in the studied tissues does not seem to be efficient.
Keywords: Alterations; Lanthanum; Lysosome; Nerve cell; Oligodendrocytes; TEM
Nedra B, Maroua M, Adrian F, Horea M, Tekaya WH, Samira M, et al. Lysosomes of Brain Cells: A Site of Handling of Lanthanum. Am J Pharmacol. 2019; 2(3): 1022.