Linlin W, Jiang H, Wang Q, Zeng L, Rui L* and Zhuorong L*
Department of Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, ChinaFulltext PDF
Alzheimer’s disease (AD) is progressive and irreversible neurodegenerative disease characterized by a deficiency in memory, language, problem solving, and other cognitive skills. Nevertheless, the mechanisms underlying the etiology of AD are still not very well understood. Long noncoding RNAs (lncRNAs) have been shown to play an important role in biological processes, such as cell differentiation, invasion, and immune responses, as well as synaptic plasticity and memory. In this study, we selected 1-month-old, 3-month-old, 6-month-old, and 9-month-old APP/PS1 transgenic mice, along with their corresponding age-matched Wild-Type (WT) mice, which were used as controls to carry out lncRNA microarray analysis. Our results show that there were 554 upregulated lncRNAs and 346 downregulated lncRNAs in 1-month-old APP/PS1 mice, 635 upregulated lncRNAs and 362 downregulated lncRNAs in 3-month-old APP/PS1 mice, 362 upregulated lncRNAs and 643 downregulated lncRNAs in 6-month-old APP/PS1 mice, and 1145 upregulated lncRNAs and 649 downregulated lncRNAs in 9-month-old APP/PS1 mice, when compared to their respective age-matched WT control mice. In addition, we constructed an lncRNA-messenger RNA (mRNA)-microRNA (miRNA) network and found that the IGF-1, P2RX7, TSPO, serpin E1, EGFR, HMOX1, and NFE212 genes may play important role in the development of AD. In conclusion, our study provides a database and the basis for further molecular mechanism and functional studies of lncRNA expression in AD and may provide potential targets for the diagnosis of the disease and novel treatment options.
Alzheimer’s disease; Long noncoding RNA; Messenger RNA; Microarray; Gene ontology analysis; Kyoto encyclopedia of genes and genomes pathways
Linlin W, Jiang H, Wang Q, Zeng L, Rui L, Zhuorong L. Microarray Profile of Long Noncoding RNA and Messenger RNA Expression in an Alzheimer’s Mouse Model. Am J Pharmacol. 2019; 2(3): 1021.