Am J Pharmacol | Volume 2, Issue 2 | Research Article | Open Access

The Effect of Lactobacillus reuteri Supplementation on T-Regulator mRNA Gene Expression in Atopy Bronchial Asthma Adult Patient

Watung J¹, Hatta M^2*, Massi NM³, Natzir R⁴ and Primaguna MR⁵

¹Department of Internal Medicine, Siloam Hospitals Manado, Indonesia
²Department of Molecular Biology and Immunology, Hasanuddin University, Indonesia
³Department of Microbiology, Hasanuddin University, Indonesia
⁴Department of Biochemistry, Hasanuddin University, Indonesia
⁵Department of Internal Medicine, Hasanuddin University, Indonesia

^*Correspondance to: Hatta M 

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Abstract

Aim: To understand the T-regulator mRNA gene expression changes after L. reuteri supplementation. Methods: This research is using experimental research method, conducted in adult patients with atopy bronchial asthma that divided into two groups. The first group was supplemented with L. reuteri and the second group was given placebo. After two weeks, laboratory parameter was retested to assess T-regulator mRNA gene expression. Result: There was a significant increase in T-regulator mRNA gene expression after L. reuteri supplementation (p<0,001) and no significant changes in control group (p=0.202). The velocity of T-regulator mRNA gene expression was 38.7%. Conclusion: The increased T-regulator mRNA gene expression in L. reuteri supplemented group reflected the effectiveness of L. reuteri supplementation as therapy in adult patients with atopy bronchial asthma.

Keywords:

Atopy bronchial asthma adult patient; T-regulator mRNA gene; L. reuteri

Citation:

Watung J, Hatta M, Massi NM, Natzir R, Primaguna MR. The Effect of Lactobacillus reuteri Supplementation on T-Regulator mRNA Gene Expression in Atopy Bronchial Asthma Adult Patient. Am J Pharmacol. 2019; 2(2): 1020.