Am J Pharmacol | Volume 2, Issue 1 | Review Article | Open Access
Anurag Chaudhary*, Neeru Singh, Vipin Kumar G and Mansi Verma
Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, India
*Correspondance to: Anurag Chaudhary
Fulltext PDFIt has been found that, on inhibition of angiogenesis, many tumors develop alternative strategies for self-supply with nutrients. One of these strategies is Vasculogenic Mimicry. Vasculogenic Mimicry (VM) is de novo formation of perfusable, matrix-rich, vasculogenic-like networks by aggressive tumour cells. The initial morphologic and molecular characterization of VM was made in human melanoma in which the tumour cells were shown to co-express endothelial and tumour markers and formed channels, networks, and tubular structures that are rich in laminin, collagens IV and VI, and heparin sulphate proteoglycans, containing plasma and red blood cells, indicating a perfusion pathway for rapidly growing tumors, as well as an escape route for metastasis. Vascular mimicry was originally located in melanoma. It has since been observed in many tumors including hepatocellular carcinoma, gastric adenocarcinoma, gall bladder carcinoma, ovarian cancer and prostate cancer. This review embodies the mechanism of VM, discovered so far, along with its effect on various tumors.
Vasculogenic mimicry; Angiogenesis; Tumor proliferation; Antitumor; Cancer
Anurag, Singh N, Vipin Kumar G, Verma M. Vasculogenic Mimicry and Its Role in Cancer. Am J Pharmacol. 2019;2(1):1013.