Am J Pharmacol | Volume 1, Issue 2 | Research Article | Open Access

A Prospective Study on Prescription Pattern of Antihypertensive Drugs and Drug Interactions at a Tertiary Care Teaching Hospital

Mallappa H Shalavadi^1*, Chandrashekhar VM¹, Manohar K², Nihar K² and Srikanth DRS²

¹Department of Pharmacology, HSK College of Pharmacy, India
²Department of Clinical Pharmacy, HSK College of Pharmacy, India

^*Correspondance to: Mallappa H Shalavadi 

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Abstract

The main objective of this study was to study prescription pattern of antihypertensive drugs in Hanagal Shri Kumareshwar hospital and research centre, Bagalkot, Karnataka, India. The study was carried out from November 2013 to April 2014. Case sheets of patients diagnosed with hypertension were collected. The demographic details of the patients were collected, signs and symptoms were noted, therapeutic data was collected from the treatment chart and drug-drug interactions in the treatment were assessed by using Micromedex 2.0 software, rationality assessment was done using Joint National Committee 7 guidelines and Indian Hypertensive Guidelines-2 and statistical test was carried out using student’s t test. During the hospital stay of 150 hypertensive cases 75 patients were male and 75 patients were female, diuretics were mostly prescribed 30.63% for hypertensive patients followed by calcium channel blockers 26.13%, combination therapy was used more when compared to mono drug therapy to maintain blood pressure. Out of 150 patients 136 prescriptions were rational and 14 were irrational. During this study a total of 252 drug-drug interactions were found. Results from the study showed that the choice of anti-hypertensive drugs reasonably comply with the JNC 7 and IGH guidelines on the management of hypertension and diuretics were the first choice of agents used to treat hypertension Which confirms a fairly good degree of compliance by clinicians with JNC 7 and IGH guidelines for the treatment of hypertension.

Keywords:

Blood pressure; Diuretics; Hypertension; Kidney; Calcium channel blocker; Drug interactions

Citation:

Shalavadi MH, Chandrashekhar VM, Manohar K, Nihar K, Srikanth DRS. A Prospective Study on Prescription Pattern of Antihypertensive Drugs and Drug Interactions at a Tertiary Care Teaching Hospital. Am J Pharmacol. 2018;1(2):1010.