Am J Otolaryngol Head Neck Surg | Volume 5, Issue 3 | Research Article | Open Access

Voice Disorders Associated to COVID-19: A Theory Domain Review

Guilherme Simas do Amaral Catani1*, Aurenzo Gonçalves Mocelin2, Maria Eduarda Catani3, Alvaro João Storto Ferreira3, Gustavo de Araujo Nishimoto3 and Rogério Hamerschmidt1

1Department of Otorhinolaryngology, Federal University of Parana, Brazil
2Federal University of Parana, Brazil
3University Center of Brusque, Brazil

*Correspondance to: Guilherme Simas Amaral Catani 

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The Coronavirus Disease (COVID-19) was detected for the first time in December of 2019, since then many studies reported voice disorders associated with mild and severe COVID-19. These vocal disorders occur from many etiologies, such as neuronal, respiratory, or vocal fold disorders. Also, they can be a consequence of the damage caused by the endotracheal intubation and the inflammatory mediators or even a result of the psychogenic factors, which were explored in this revision.

Methods: The method used in this review study was the hybrid-narrative review focusing on theories and hypotheses that could explain the relationship between COVID-19 and voice disorders.

Results: The hypotheses found that the most relevant factors that could explain the voice alterations were neurotropic property evidenced on the neuronal route of infection of the SARS-CoV-2, inflammatory factor, endotracheal intubation, pulmonary function, psychogenic factor.

Conclusion: The association between COVID-19 and voice disorders seems to be a multifactorial result of mechanical traumas and metabolic alterations caused by the inflammation in COVID. The major elements seem to be trauma by endotracheal intubation, systemic inflammatory repercussion, and direct neuronal damage related to the neurotropism of the virus.


Voice disorders; Dysphonia; Speech language pathology; Multifactorial causalities; COVID-19


do Amaral Catani GS, Mocelin AG, Catani ME, Storto Ferreira AJ, de Araujo Nishimoto G, Hamerschmidt R. Voice Disorders Associated to COVID-19: A Theory Domain Review. Am J Otolaryngol Head Neck Surg. 2022; 5(3): 1181..

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