Am J Leuk Res | Volume 5, Issue 1 | Case Report | Open Access
Santarsiero Sara*, De Vincentiis Giovanni, Tucci Filippo Maria, Partipilo Paolo and Sitzia Emanuela
Department of Otolaryngology, Bambino Gesù Children’s Hospital, 00165, Rome, Italy
*Correspondance to: Sara Santarsiero
Fulltext PDFLaryngeal Mucosa-Associated Lymphoid Tissue (MALT) lymphoma is an extremely rare tumor in general population, even more in childhood. Etiopathogenesis remains unknown. Immunological disorders, chronic inflammation and viral infections in genetically predisposed patients are the main suspected causal conditions. Potentially, the tumor may origin in every laryngeal subsite, but supraglottic seems to be primarily involved for the embryological development and the anatomical characteristics of the mucosa and the associated lymphoid system. By consequence, the onset symptoms may be different: Dysphagia, dysphonia, chronic cough, and dyspnea, with progressive worsening in relation to the mass extension in the larynx and hypopharynx. Systemic symptoms as weight loss, night sweats and fever are rare, more often associated with B-cell types or systemic disease. For the first evaluation a fibrolaryngoscopy is required, but the macroscopical aspect of the tumor is not pathognomonic so an incisional or excisional biopsy is needed for histological and immunochemical diagnosis. After diagnosis, the management is mainly oncohematological. ENT specialist may be useful for the first diagnostic approach and for the follow-up of local disease by fibrolaryngoscopy. We reported a rare case of laryngeal, supraglottic MALT in a 9-year-old girl. Surgical removal of the mass had been the only treatment performed in this case, which is still in follow-up, without signs of relapse or persistent disease until now. We think the fibrolaryngoscopy should be always performed when symptoms are persistent or worsening. In case of doubt, surgical removal and anatomic pathological exams are required even when the lesion’s appearance is benign. Early diagnosis may guarantee a better local and systemic control of disease, reducing the risk of wide asportations and adjuvant radiotherapy, chemotherapy, or biological immunotherapy.
MALT lymphoma; Laryngeal lymphoma; Laryngeal tumors; Pediatric lymphoma; NHL lymphoma, Marginal zone B-cell non-Hodgkin lymphoma
Santarsiero S, De Vincentiis G, Tucci FM, Partipilo P, Sitzia E. A Rare and Unexpected Pediatric Case of MALT Lymphoma of the Larynx. Am J Leuk Res. 2022; 5(1): 1023.