Akhlaq Ahmad, Asif Hayat, Mati Ur Rahman and Javed Khan
Department of Chemistry, Fuzhou University, PR China
Department of Chemistry, Sun Yat-Sen University, PR China
The ongoing enhanced resistances of pathogens against antibiotics frequently single mode of
action are amongst one of the major clinical challenges that entail rapid and novel alternatives.
Antimicrobial Photo Dynamic Therapy (APDT) is a feasible choice that manifests multiple target
site action and predicted to proliferate in upcoming days. The photo sensitizers are activated during
light visible wavelength spectra from 400 nm to 700 nm which in turn forms free radicals that
immediately kills pathogens. This review summarized the newly synthesized photosensitizes such as
phthalocyanines, porphyrins and phenothiazinium derivatives which are widely investigated. Zinc
phthalocyanine conjugates establishing efficient binding, visible spectra, and investigation assured
confiscating toxicity both in vitro and in vivo models. The Zinc phathalocyannine conjugated with
pent lysine and conjugated with variable charges especially n+8 exhibited high inhibition towards
multi drug resistance bacteria. Phthalocyanines get much more benefits on basis of industrial
applications such as pigment dye used in fabric and manifested an enormous candidate for friendly
environment. Similarly the concern materials depicting a booming stability along with their
fabulous photochemical and photo physical properties in semiconductor, solar cells, optical data,
sensors and photo catalysts and also demonstrating a vial therapy in the antimicrobial or antitumor
applications. Photo antimicrobial therapy is gaining significant importance, as a new alternative
that could slow the pace of resistance development in pathogens. However, the global and national
authorities should provide proper funding, market space and should have the courage to practice.
Ahmad A, Hayat A, Rahman MU, Khan J. Phthalocyanines Derivatives as Control Approach for Antimicrobial
Photodynamic Therapy. Am J Clin Microbiol Antimicrob. 2019; 2(3): 1041.